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pentobarbital will lessen the extent or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of abemaciclib with strong CYP3A4 inducers minimizes plasma concentration of abemaciclib and its metabolites.Indications exceptional to seizure and seizures auras are melancho